Other commonly used NSAIDs, such as Bute or Banamine, inhibit both inflammatory cyclooxygenase enzymes (COX-2) as well as the gastro-protective form of the enzyme (COX-1). The COX-1 inhibitory activity of these products and associated gastrointestinal side effects, including ulcers, make them unsafe for long-term daily use.
Conversely, resveratrol does not affect the body’s production of gastroprotective prostaglandins and does not have unwanted gastrointestinal side effects. Rather than inhibiting inflammatory enzymes circulating in the body, resveratrol reduces gene expression of inflammatory mediators, such as COX-2, lipoxygenases, myeloperoxidases, nitrous oxide synthases and tumor necrosis factor alpha (TNFα). The result is that lower concentrations of inflammatory enzymes are circulating in the body.
Equithrive products contain a proprietary resveratrol ingredient called Resverasyn™. Resverasyn™ is manufactured by a pharmaceutical company that is audited by the United States Food and Drug Administration (FDA). Each production lot of Resverasyn™ is analyzed via high pressure liquid chromatography (HPLC) to ensure that the product meets our 99% purity specification before it is incorporated into Equithrive brand products.
Resverasyn™ has been micronized and encapsulated to maximize the bioavailability and stability of the product. Micronization is a process that reduces the particle size of resveratrol so that its bioavailability is enhanced. Encapsulation is a process whereby resveratrol molecules are covered in a protective coating. This process protects resveratrol particles from deterioration with exposure to light. Encapsulation also contributes to the bioavailability of resveratrol by allowing more of the molecule to enter the bloodstream and to be transported throughout the body for maximum therapeutic effect.
Resveratrol (trans-3,5,4′-Trihydroxystilbene) belongs to a class of natural compounds called stilbenes. Resveratrol and other stilbenes are small molecules that are rapidly synthesized by plants in response to attacks by bacteria, fungi and predators. Stilbenes presently are the focus of numerous biomedical research studies. Compounds within this chemical class have displayed therapeutic potential in metabolic, cardiovascular and neurodegenerative diseases as well as in various forms of cancer.
Resveratrol typically is associated with grapes and red wine. However, the concentration of resveratrol in wine, grapes, grape skin extracts and grape seed extracts is extremely low. The primary commercial source of resveratrol is a shrub named Japanese Knotweed (Polygonum cuspidatum) that is native to Asia. This plant is cultivated in China. Chinese manufacturing firms extract resveratrol from the rhizomes (underground stems) of the shrub.
Chinese manufacturing firms produce Knotweed extracts that have resveratrol concentrations ranging from 20% to 98%. The corresponding percentage of impurities in these resveratrol products ranges from 2 to 80%. One of the impurities in Knotweed-based resveratrol products is a compound called emodin. This impurity has caused serious gastrointestinal distress in many people that have used Knotweed-based resveratrol products. The questionable purity and safety of Chinese resveratrol products derived from Japanese Knotweed raises cause for concern.
Use Equithrive brand products with Resverasyn™ and be certain that your horse is receiving therapeutic doses of pure bioavailable resveratrol!